Protein-, (Poly)peptide-, and Amino Acid-Based Nanostructures Prepared via Polymerization-Induced Self-Assembly

Proteins and peptides, built from precisely defined amino acid sequences, are an important class of biomolecules that play a vital role in most biological functions. Preparation nanostructures through functionalization natural, hydrophilic proteins/peptides with synthetic polymers or upon self-assembly all-synthetic amphiphilic copolypept(o)ides acid-containing enables access to novel protein-mimicking biomaterials superior physicochemical properties immense biorelevant scope. In recent years, polymerization-induced (PISA) has been established as efficient versatile alternative method existing procedures for the reproducible development block copolymer nano-objects situ at high concentrations and, thus, provides ideal platform engineering protein-inspired nanomaterials. this review article, different strategies employed direct construction protein-, (poly)peptide-, acid-based via PISA described particular focus on characteristics developed assemblies, well their utilization various pharmaceutical biomedical applications.